Comparison of in vitro antifungal activities of efinaconazole and 1 currently available antifungal agents against a variety of pathogenic 2 fungi associated with onychomycosis 3 4
نویسندگان
چکیده
Comparison of in vitro antifungal activities of efinaconazole and 1 currently available antifungal agents against a variety of pathogenic 2 fungi associated with onychomycosis 3 4 William J. Jo Siu, Yoshiyuki Tatsumi, Hisato Senda, Radhakrishnan Pillai, Takashi 5 Nakamura, Daisuke Sone, Annette Fothergill 6 7 Dow Pharmaceutical Sciences, a Division of Valeant Pharmaceuticals North America 8 LLC, 1330 Redwood Way, Petaluma, CA 94954, U.S.A. 9 Kaken Pharmaceutical Company, Ltd., 14, Shinomiya, Minamigawara-cho, Yamashina10 ku, Kyoto 607-8042, Japan 11 University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San 12 Antonio, TX 78229, U.S.A. 13 14 Corresponding author 15 Tel.: 707-793-2600 16 Fax: 707-793-0145 17 Email: [email protected] 18 19 Running Title: In vitro antifungal activity of efinaconazole 20
منابع مشابه
Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis.
Onychomycosis is a common fungal nail infection in adults that is difficult to treat. The in vitro antifungal activity of efinaconazole, a novel triazole antifungal, was evaluated in recent clinical isolates of Trichophyton rubrum, Trichophyton mentagrophytes, and Candida albicans, common causative onychomycosis pathogens. In a comprehensive survey of 1,493 isolates, efinaconazole MICs against ...
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Onychomycosis is a fungal nail infection which is relatively common and difficult to treat. Treatment modalities include nail avulsion, surgical debridement and combination therapy with oral and topical antifungal drugs. In spite of a host of available drugs, clinical cure rates remain discouraging. Drug toxicities, prolonged regimens, lack of patient compliance, and high keratin affinity of dr...
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To provide an adequate therapeutic effect against onychomycosis, it has been suggested that topical drugs should have two properties: drug permeability through the nail plate and into the nail bed, and retention of their antifungal activity in the disease-affected areas. Only recently has the importance of other delivery routes (such as subungual) been discussed. Efinaconazole has been shown to...
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Use of oral antifungals in the treatment of onychomycosis is commonplace; but their use can be limited by safety and patient concerns. Due to their broader safety margins, topical antifungals (efinaconazole, tavaborole, and ciclopirox) are a useful option in the treatment of mild-to-moderate onychomycosis in the USA, but their antifungal activity has yet to be directly compared. This study aims...
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Background and Purpose: Candida species are the most opportunistic fungi affecting the nails and resulting in onychomycosis. In this study, we identified and evaluated in-vitro susceptibility of the recovered isolates against fluconazole (FLC), voriconazole (VRC), and clotrimazole (CLT) using the Clinical and Laboratory Standards Institute (CLSI) M27-A3 document. Materials and Method...
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